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    recombinant-human-cathepsin-c-protein-ab158099.pdf

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Recombinant Human Cathepsin C protein (ab158099)

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SDS-PAGE - Recombinant Human Cathepsin C protein (ab158099)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

    Description

    • Product name

      Recombinant Human Cathepsin C protein
      See all Cathepsin C proteins and peptides
    • Expression system

      Wheat germ
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQR DVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYK WFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVY VNTAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGD MIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVR NQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGG FYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPF ELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAI ESIAVAATPIPKL
      • Amino acids

        1 to 463
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab158099 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      Western blot

    • Form

      Liquid
    • Additional notes

      This product was previously labelled as DPP1.

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • AI047818
      • CATC
      • CATC_HUMAN
      • Cathepsin C
      • Cathepsin J
      • CPPI
      • CTSC
      • Dipeptidyl peptidase 1
      • Dipeptidyl peptidase 1 light chain
      • Dipeptidyl peptidase I
      • Dipeptidyl peptidase I exclusion domain chain
      • Dipeptidyl peptidase I heavy chain
      • Dipeptidyl peptidase I light chain
      • Dipeptidyl transferase
      • DPP I
      • DPP-I
      • DPPI
      • EC 3.4.14.1
      • HMS
      • JP
      • JPD
      • MGC126959
      • PALS
      • PDON1
      • PLS
      see all
    • Function

      Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.
    • Tissue specificity

      Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.
    • Involvement in disease

      Papillon-Lefevre syndrome
      Haim-Munk syndrome
      Periodontititis, aggressive, 1
    • Sequence similarities

      Belongs to the peptidase C1 family.
    • Post-translational
      modifications

      N-glycosylated. While glycosylation at Asn-53, Asn-119 and Asn-276 is mediated by STT3A-containing complexes, glycosylation at Asn-29 is mediated STT3B-containing complexes.
      In approximately 50% of the complexes the exclusion domain is cleaved at position 58 or 61. The two parts of the exclusion domain are held together by a disulfide bond.
    • Cellular localization

      Lysosome.
    • Target information above from: UniProt accession P53634 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human Cathepsin C protein (ab158099)
      SDS-PAGE - Recombinant Human Cathepsin C protein (ab158099)
      ab158099 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab158099? Please let us know so that we can cite the reference in this datasheet.

    ab158099 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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