Recombinant Human Cathepsin C protein (ab158099)
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- References
- Protocols
Overview
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Product nameRecombinant Human Cathepsin C protein
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Protein lengthFull length protein
Description
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NatureRecombinant
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SourceWheat germ
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Amino Acid Sequence
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SpeciesHuman
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SequenceMGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQR DVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYK WFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVY VNTAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGD MIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVR NQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGG FYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPF ELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAI ESIAVAATPIPKL
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Amino acids1 to 463
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TagsGST tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab158099 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
ELISA
Western blot
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FormLiquid
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Additional notesProtein concentration is above or equal to 0.05 mg/ml.
This product was previously labelled as DPP1
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- AI047818
- CATC
- CATC_HUMAN
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FunctionThiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.
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Tissue specificityUbiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.
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Involvement in diseasePapillon-Lefevre syndrome
Haim-Munk syndrome
Periodontititis, aggressive, 1 -
Sequence similaritiesBelongs to the peptidase C1 family.
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Post-translational
modificationsN-glycosylated. While glycosylation at Asn-53, Asn-119 and Asn-276 is mediated by STT3A-containing complexes, glycosylation at Asn-29 is mediated STT3B-containing complexes.
In approximately 50% of the complexes the exclusion domain is cleaved at position 58 or 61. The two parts of the exclusion domain are held together by a disulfide bond. -
Cellular localizationLysosome.
- Information by UniProt
Images
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SDS-PAGE - Recombinant Human Cathepsin C protein (ab158099)ab158099 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Datasheets and documents
References
ab158099 has not yet been referenced specifically in any publications.
