Recombinant Human CATSPER3 protein (ab166329)

Our Abpromise guarantee covers the use of ab166329 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- Ca(v)-like protein
- CACRC
- calcium channel repeat containing 1
- Cation channel sperm-associated protein 3
- Cation channel, sperm associated 3
- CatSper3
- CTSR3_HUMAN
- One-repeat calcium channel-like protein
- putative ion channel CatSper3
see all
Function

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
Tissue specificity

Testis-specific.
Sequence similarities

Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
Cellular localization

Cell projection > cilium > flagellum membrane. Specifically located in the principal piece of sperm tail.
Target information above from: UniProt accession Q86XQ3 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human CATSPER3 protein (ab166329)

ab166329 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ab166329 has not yet been referenced specifically in any publications.

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