Recombinant Human CATSPER3 protein (ab166329)
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Overview
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Product nameRecombinant Human CATSPER3 protein
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Protein lengthProtein fragment
Description
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NatureRecombinant
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SourceWheat germ
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Amino Acid Sequence
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SpeciesHuman
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SequenceQRQQEEISRLMHIQKNADCTSFSELVENFKKTLSHTDPMVLDDFGTSLPF IDIYFSTLDYQDTTVHKLQELYYEIVHVLSLMLEDLPQEKPQSLEKVDEK
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Amino acids299 to 398
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Tagsproprietary tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab166329 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
ELISA
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FormLiquid
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Additional notesProtein concentration is above or equal to 0.05 mg/ml.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- Ca(v)-like protein
- CACRC
- calcium channel repeat containing 1
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FunctionVoltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
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Tissue specificityTestis-specific.
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Sequence similaritiesBelongs to the cation channel sperm-associated (TC 1.A.1.19) family.
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Cellular localizationCell projection > cilium > flagellum membrane. Specifically located in the principal piece of sperm tail.
- Information by UniProt
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Datasheets and documents
References
ab166329 has not yet been referenced specifically in any publications.