Recombinant Human CATSPER3 protein (ab166329)

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Overview

  • Product name
    Recombinant Human CATSPER3 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      QRQQEEISRLMHIQKNADCTSFSELVENFKKTLSHTDPMVLDDFGTSLPF IDIYFSTLDYQDTTVHKLQELYYEIVHVLSLMLEDLPQEKPQSLEKVDEK
    • Amino acids
      299 to 398
    • Tags
      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab166329 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Ca(v)-like protein
    • CACRC
    • calcium channel repeat containing 1
    • Cation channel sperm-associated protein 3
    • Cation channel, sperm associated 3
    • CatSper3
    • CTSR3_HUMAN
    • One-repeat calcium channel-like protein
    • putative ion channel CatSper3
    see all
  • Function
    Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
  • Tissue specificity
    Testis-specific.
  • Sequence similarities
    Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
  • Cellular localization
    Cell projection > cilium > flagellum membrane. Specifically located in the principal piece of sperm tail.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human CATSPER3 protein (ab166329)
    SDS-PAGE - Recombinant Human CATSPER3 protein (ab166329)
    ab166329 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab166329 has not yet been referenced specifically in any publications.

Publishing research using ab166329? Please let us know so that we can cite the reference in this datasheet.

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