Recombinant Human Caveolin-1 protein (ab114170)

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SDS-PAGE - Recombinant Human Caveolin-1 protein (ab114170)
  • Western blot - Recombinant Human Caveolin-1 protein (ab114170)

Key features and details

  • Expression system: Wheat germ
  • Suitable for: SDS-PAGE, WB, ELISA

Description

  • Product name

    Recombinant Human Caveolin-1 protein
    See all Caveolin-1 proteins and peptides

  • Expression system

    Wheat germ

  • Accession

    Q03135

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEID LVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFY RLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSI YVHTVCDPLFEAVGKIFSNVRINLQKEI

    • Predicted molecular weight

      46 kDa including tags

    • Amino acids

      1 to 178

    • Additional sequence information

      There is a GST tag at N-terminal end.

Specifications

Our Abpromise guarantee covers the use of ab114170 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • BSCL3
    • CAV
    • CAV1
    • CAV1_HUMAN
    • caveolae protein, 22 kD
    • caveolin 1 alpha isoform
    • caveolin 1 beta isoform
    • Caveolin 1 caveolae protein 22kDa
    • Caveolin-1
    • Caveolin1
    • cell growth-inhibiting protein 32
    • CGL3
    • LCCNS
    • MSTP085
    • OTTHUMP00000025031
    • PPH3
    • VIP 21
    • VIP21
    see all

  • Function

    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.

  • Tissue specificity

    Expressed in muscle and lung, less so in liver, brain and kidney.

  • Involvement in disease

    Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.

  • Sequence similarities

    Belongs to the caveolin family.

  • Post-translational
    modifications

    The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.

  • Cellular localization

    Golgi apparatus membrane. Cell membrane. Membrane > caveola. Membrane raft. Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human Caveolin-1 protein (ab114170)
    SDS-PAGE - Recombinant Human Caveolin-1 protein (ab114170)
    ab114170 on a 12.5% SDS-PAGE Stained with Coomassie Blue.
  • Western blot - Recombinant Human Caveolin-1 protein (ab114170)
    Western blot - Recombinant Human Caveolin-1 protein (ab114170)

    ab18199 recognizes the full length tagged recombinant Caveolin 1 protein (ab114170) which has an expected molecular weight of 46 kDa.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab114170? Please let us know so that we can cite the reference in this datasheet.

ab114170 has not yet been referenced specifically in any publications.

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