Recombinant Human Cbl-c protein (ab161722)

Our Abpromise guarantee covers the use of ab161722 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- Cas Br M (murine) ecotropic retroviral transforming sequence c
- Cas Br M (murine) ectropic retroviral transforming sequence c
- Casitas B lineage lymphoma c
- CBL 3
- Cbl proto-oncogene C, E3 ubiquitin protein ligase
- Cbl proto-oncogene, E3 ubiquitin protein ligase C
- CBL SL
- E3 ubiquitin-protein ligase CBL-C
- RING finger protein 57
- RNF57
- SH3 binding protein CBL C
- SH3-binding protein CBL-3
- Signal transduction protein CBL C
see all
Relevance

Cblc belongs to a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cblc is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitous). Cblc, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cblc knock out mice show no obvious phenotype. Thus, the physiological role of Cblc is not known.
Cellular localization

Nuclear

SDS-PAGE - Recombinant Human Cbl-c protein (ab161722)

ab161722 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ab161722 has not yet been referenced specifically in any publications.

Publishing research using ab161722? Please let us know so that we can cite the reference in this datasheet.

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