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Immunology Innate Immunity Chemokines Beta Chemokines (CC)
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Bioactive grade

Recombinant human CCL14 protein (Active) (ab243282)

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SDS-PAGE - Recombinant human CCL14 protein (Active) (ab243282)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 95% SDS-PAGE
    • Endotoxin level: < 1.000 Eu/µg
    • Active: Yes
    • Suitable for: HPLC, SDS-PAGE, Functional Studies

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    Description

    • Product name

      Recombinant human CCL14 protein (Active)
      See all CCL14 proteins and peptides
    • Biological activity

      Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 5.0 - 20 ng/ml.

    • Purity

      > 95 % SDS-PAGE.
      >95% as determined by SDS-PAGE and HPLC.
    • Endotoxin level

      < 1.000 Eu/µg
    • Expression system

      Escherichia coli
    • Accession

      Q16627
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        GPYHPSECCFTYTTYKIPRQRIMDYYETNSQCSKPGIVFITKRGHSVCTN PSDKWVQDYIKDMKEN
      • Predicted molecular weight

        8 kDa
      • Amino acids

        28 to 93
      • Additional sequence information

        Full length mature HCC-1 (9-74) chain.

    Associated products

      Specifications

      Our Abpromise guarantee covers the use of ab243282 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      • Applications

        HPLC

        SDS-PAGE

        Functional Studies

      • Form

        Lyophilized
      • Concentration information loading...

      Preparation and Storage

      • Stability and Storage

        Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

        Constituent: PBS

        0.2 µm filtered

        This product is an active protein and may elicit a biological response in vivo, handle with caution.

      • Reconstitution
        We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at = -20 °C. Further dilutions should be made in appropriate buffered solutions.

      General Info

      • Alternative names

        • CC-1
        • CC-3
        • CCL14
        • CCL14_HUMAN
        • chemokine (C-C motif) ligand 14
        • Chemokine CC-1/CC-3
        • chemokine CC1
        • chemokine CC3
        • chemokine HCC1
        • chemokine HCC3
        • CKb1
        • HCC 1
        • HCC 3
        • HCC-1(1-74)
        • HCC-1(9-74)
        • HCC-1/HCC-3
        • HCC-3
        • HCC1
        • HEMOFILTRATE CC CHEMOKINE 1
        • MCIF
        • NCC-2
        • NCC2
        • new CC chemokine 2
        • SCYA14
        • SCYL2
        • small inducible cytokine subfamily A (Cys-Cys), member 14
        • Small-inducible cytokine A14
        • SY14
        see all
      • Function

        Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
      • Tissue specificity

        Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.
      • Sequence similarities

        Belongs to the intercrine beta (chemokine CC) family.
      • Post-translational
        modifications

        The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.
        HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.
      • Cellular localization

        Secreted.
      • Target information above from: UniProt accession Q16627 The UniProt Consortium
        The Universal Protein Resource (UniProt) in 2010
        Nucleic Acids Res. 38:D142-D148 (2010) .

        Information by UniProt

      Images

      • SDS-PAGE - Recombinant human CCL14 protein (Active) (ab243282)
        SDS-PAGE - Recombinant human CCL14 protein (Active) (ab243282)
        SDS-PAGE analysis of ab243282

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab243282? Please let us know so that we can cite the reference in this datasheet.

      ab243282 has not yet been referenced specifically in any publications.

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      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com

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