Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHHSSGLVPRGSHMGSEVKYLGQLTSIPGYLNPSSRTEILHFI DNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAV SYVRDDAAHLVVLKTDDSSTKVDIKETYEVEASTFCFPESVDVGGASPHS KTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHE FCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITD SFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDISSDIE ALGCSMDQDSA
    • Molecular weight
      34 kDa including tags
    • Amino acids
      66 to 353
    • Tags
      His tag N-Terminus
    • Additional sequence information
      NCBI Accession No.: NP_001161407

Specifications

Our Abpromise guarantee covers the use of ab174451 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    >90% by SDS-PAGE.
    ab174451 was purified using conventional chromatography.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • C7orf22
    • Ccm2
    • CCM2 gene
    • CCM2_HUMAN
    • Cerebral cavernous malformation 2
    • Cerebral cavernous malformations 2 protein
    • Chromosome 7 open reading frame 22
    • Malcavernin
    • MGC4067
    • MGC4607
    • MGC74868
    • OSM
    • Osmosensing scaffold for MEKK3
    • OTTHUMP00000159554
    • OTTHUMP00000214270
    • OTTHUMP00000214271
    • OTTHUMP00000214273
    • PP10187
    see all
  • Function
    May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
  • Involvement in disease
    Defects in CCM2 are the cause of cerebral cavernous malformations type 2 (CCM2) [MIM:603284]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and are usually present clinically during the 3rd to 5th decades of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.
  • Sequence similarities
    Contains 1 PID domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab174451 (3 µg)

References

ab174451 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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