Recombinant Human CCR4 protein (ab253173)

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Description

  • Product name

    Recombinant Human CCR4 protein

  • Expression system

    Wheat germ

  • Accession

    P51679

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVF VFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAA DQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRART LTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKV LSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVL FLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQS TMDHDLHDAL

    • Predicted molecular weight

      41 kDa

    • Amino acids

      1 to 360

    • Additional sequence information

      NP_005499.1

Specifications

Our Abpromise guarantee covers the use of ab253173 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Form

    Liquid

  • Additional notes

    Prepared in an in vitro wheat germ expression system with proprietary liposome technology. By using a mRNA having 5’cap and a poly(A)-tail with this extract in combination with a proprietary liposome, the translation reaction in vitro yields ample quantity of membrane protein which is captured by the liposome leading to correct conformation and folding essential for biological function.

    Heating may cause protein aggregation. Please do not heat this product before electrophoresis.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.4% Tris HCl, 2% Glycerol

General Info

  • Alternative names

    • C C chemokine receptor type 4
    • C C CKR 4
    • C-C chemokine receptor type 4
    • C-C CKR-4
    • CC CKR 4
    • CC-CKR-4
    • CCR 4
    • CCR-4
    • CCR4
    • CCR4_HUMAN
    • CD194
    • Chemokine (CC motif) receptor 4
    • chemokine C C motif receptor 4
    • ChemR13
    • CKR4
    • CMKBR 4
    • CMKBR4
    • HGCN 14099
    • K5 5
    • K5-5
    • MGC88293
    see all

  • Function

    High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

  • Tissue specificity

    Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.

  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.

  • Post-translational
    modifications

    In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.

  • Cellular localization

    Cell membrane.
  • Information by UniProt

References

ab253173 has not yet been referenced specifically in any publications.

Publishing research using ab253173? Please let us know so that we can cite the reference in this datasheet.

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