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    recombinant-human-cd10-protein-ab157051.pdf

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Immunology Adaptive Immunity B Cells CD
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Recombinant human CD10 protein (ab157051)

  • Datasheet
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SDS-PAGE - Recombinant human CD10 protein (ab157051)

    Key features and details

    • Expression system: Baculovirus infected Sf9 cells
    • Purity: > 95% SDS-PAGE
    • Active: Yes
    • Tags: His tag N-Terminus
    • Suitable for: Functional Studies, SDS-PAGE

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    Description

    • Product name

      Recombinant human CD10 protein
      See all CD10 proteins and peptides
    • Biological activity

      1140 pmol/min/µg (9 ng NEP were used to cleave 10µM Mca-RPPGFSAFK(Dnp)-OH (Fluorogenic Substrate) at 37°C in 50 mM TRIS, pH 9.0).

    • Purity

      > 95 % SDS-PAGE.
      ab157051 has been purified in the glycosylated soluble form.
    • Expression system

      Baculovirus infected Sf9 cells
    • Accession

      P08473
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        DDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSS RYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSR GGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLIN LFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISV ARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNK MTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYL TKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTT SETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFI QTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNY KEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQ IVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGD LVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADN GGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEY AVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
      • Predicted molecular weight

        85 kDa including tags
      • Amino acids

        53 to 750
      • Tags

        His tag N-Terminus

    Associated products

    • Related Products

      • Anti-6X His tag® antibody [HIS.H8] (ab18184)
      • Anti-6X His tag® antibody [4D11] (ab5000)
      • Anti-6X His tag® antibody (ab9108)

    Specifications

    Our Abpromise guarantee covers the use of ab157051 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Functional Studies

      SDS-PAGE

    • Form

      Liquid
    • Additional notes

      Stable on ice for at least 1h. Do not freeze in dilute form.
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle. Please see notes section.

      Constituents: 0.61% Tris, 20% Glycerol (glycerin, glycerine), 1.75% Sodium chloride

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    General Info

    • Alternative names

      • Atriopeptidase
      • CALLA
      • CD10
      • CD10 antigen
      • Common acute lymphocytic leukemia antigen
      • DKFZp686O16152
      • EC 3.4.24.11
      • Enkephalinase
      • EPN
      • Membrane metallo endopeptidase
      • Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase)
      • Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
      • Membrane metallo endopeptidase variant 1
      • Membrane metallo endopeptidase variant 2
      • Membrane metalloendopeptidase
      • Membrane metalloendopeptidase neutral endopeptidase enkephalinase
      • Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10
      • Membrane metalloendopeptidase variant 1
      • Membrane metalloendopeptidase variant 2
      • MGC126681
      • MGC126707
      • MME
      • NEP
      • NEP_HUMAN
      • Neprilysin
      • neprilysin-390
      • neprilysin-411
      • Neutral endopeptidase
      • Neutral endopeptidase 24.11
      • Neutral endopeptidase, membrane-associated
      • SFE
      • Skin fibroblast elastase
      see all
    • Function

      Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
    • Sequence similarities

      Belongs to the peptidase M13 family.
    • Cellular localization

      Cell membrane.
    • Target information above from: UniProt accession P08473 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant human CD10 protein (ab157051)
      SDS-PAGE - Recombinant human CD10 protein (ab157051)
      SDS-PAGE Analysis of 1.0 μg of purified ab157051.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (1)

    Publishing research using ab157051? Please let us know so that we can cite the reference in this datasheet.

    ab157051 has been referenced in 1 publication.

    • Yu S  et al. A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1. Adv Sci (Weinh) 8:e2101848 (2021). PubMed: 34363355

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