Recombinant Human CD11b protein (ab126010)

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Description

  • Product name

    Recombinant Human CD11b protein

  • Expression system

    Escherichia coli

  • Accession

    P11215

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Predicted molecular weight

      29 kDa

    • Amino acids

      567 to 825

Specifications

Our Abpromise guarantee covers the use of ab126010 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • antigen CD11b (p170)
    • Antigen CD11b p170
    • CD11 antigen like family member B
    • CD11 antigen-like family member B
    • CD11b
    • CD11b/CD18
    • CD49d
    • Cell surface glycoprotein MAC-1 subunit alpha
    • Complement component 3 receptor 3 subunit
    • Complement Component Receptor 3 Alpha
    • Complement receptor type 3
    • Complement receptor type 3, alpha subunit
    • CR 3 alpha chain
    • CR 3 alpha chain (CR3A)
    • CR-3 alpha chain
    • CR3
    • CR3A
    • F730045J24Rik
    • Integrin Alpha M
    • Integrin alpha M chain
    • Integrin alpha-M
    • Integrin beta 2 alpha subunit
    • Integrin subunit alpha M
    • integrin, alpha M (complement component 3 receptor 3 subunit)
    • ITAM_HUMAN
    • ITGAM
    • Leukocyte adhesion receptor MO1
    • Ly-40
    • MAC 1
    • Mac-1a
    • MAC1
    • Mac1, alpha subunit
    • MAC1A
    • Macrophage antigen alpha polypeptide
    • MGC117044
    • Mo1
    • Mo1, alpha subunit
    • MO1A
    • Neutrophil adherence receptor
    • Neutrophil adherence receptor alpha M subunit
    • SLEB6
    see all

  • Function

    Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

  • Tissue specificity

    Predominantly expressed in monocytes and granulocytes.

  • Involvement in disease

    Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

  • Sequence similarities

    Belongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
    Contains 1 VWFA domain.

  • Domain

    The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

  • Cellular localization

    Membrane.
  • Information by UniProt

References

ab126010 has not yet been referenced specifically in any publications.

Publishing research using ab126010? Please let us know so that we can cite the reference in this datasheet.

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