Overview

  • Product name
    Recombinant Human CD11b protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
      P11215
    • Species
      Human
    • Molecular weight
      29 kDa
    • Amino acids
      567 to 825

Specifications

Our Abpromise guarantee covers the use of ab126010 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names
    • antigen CD11b (p170)
    • Antigen CD11b p170
    • CD11 antigen like family member B
    • CD11 antigen-like family member B
    • CD11b
    • CD11b/CD18
    • CD49d
    • Cell surface glycoprotein MAC-1 subunit alpha
    • Complement component 3 receptor 3 subunit
    • Complement Component Receptor 3 Alpha
    • Complement receptor type 3, alpha subunit
    • CR 3 alpha chain
    • CR 3 alpha chain (CR3A)
    • CR-3 alpha chain
    • CR3
    • CR3A
    • F730045J24Rik
    • Integrin Alpha M
    • Integrin alpha M chain
    • Integrin alpha-M
    • Integrin beta 2 alpha subunit
    • Integrin subunit alpha M
    • integrin, alpha M (complement component 3 receptor 3 subunit)
    • ITAM_HUMAN
    • ITGAM
    • Leukocyte adhesion receptor MO1
    • Ly-40
    • MAC 1
    • Mac-1a
    • MAC1
    • Mac1, alpha subunit
    • MAC1A
    • Macrophage antigen alpha polypeptide
    • MGC117044
    • Mo1, alpha subunit
    • MO1A
    • Neutrophil adherence receptor
    • Neutrophil adherence receptor alpha M subunit
    • SLEB6
    see all
  • Function
    Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
  • Tissue specificity
    Predominantly expressed in monocytes and granulocytes.
  • Involvement in disease
    Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
  • Sequence similarities
    Belongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
    Contains 1 VWFA domain.
  • Domain
    The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Cellular localization
    Membrane.
  • Information by UniProt

References

ab126010 has not yet been referenced specifically in any publications.

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