Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMQKSSIE KCSVDIQQSR NKTTERPGLL NCPIYWQQLR EKCLLFSHTV NPWNNSLADC STKESSLLLI RDKDELIHTQ NLIRDKAILF WIGLNFSLSE KNWKWINGSF LNSNDLEIRG DAKENSCISI SQTSVYSEYC STEIRWICQK ELTPVRNKVY PDS
    • Molecular weight

      21 kDa including tags
    • Amino acids

      67 to 225
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab131668 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    > 85 % SDS-PAGE.

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • C-type lectin domain family 5 member B
    • CD161
    • CLEC5B
    • HNKR-P1a
    • Killer Cell Lectin like Receptor Subfamily B Member 1
    • Killer cell lectin-like receptor subfamily B member 1
    • KLRB1
    • KLRB1_HUMAN
    • Natural killer cell surface protein P1A
    • NKR
    • NKR P1
    • NKR-P1A
    • NKRP1
    • NKRP1A
    see all
  • Function

    Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
  • Tissue specificity

    Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
  • Sequence similarities

    Contains 1 C-type lectin domain.
  • Post-translational
    modifications

    N-glycosylated. Contains sialic acid residues.
  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab131668 at approximately 21.0 kDa (3µg).

References

ab131668 has not yet been referenced specifically in any publications.

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