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Immunology Adaptive Immunity B Cells CD
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Recombinant Human CD166 protein (Fc Chimera) (ab191959)

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SDS-PAGE - Recombinant Human CD166 protein (Fc Chimera) (ab191959)

    Key features and details

    • Expression system: HEK 293 cells
    • Purity: > 95% SDS-PAGE
    • Endotoxin level: < 1.000 Eu/µg
    • Suitable for: SDS-PAGE

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    Description

    • Product name

      Recombinant Human CD166 protein (Fc Chimera)
      See all CD166 proteins and peptides
    • Purity

      > 95 % SDS-PAGE.

    • Endotoxin level

      < 1.000 Eu/µg
    • Expression system

      HEK 293 cells
    • Accession

      Q13740
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        WYTVNSAYGDTIIIPCRLDVPQNLMFGKWKYEKPDGSPVFIAFRSSTKKS VQYDDVPEYKDRLNLSENYTLSISNARISDEKRFVCMLVTEDNVFEAPTI VKVFKQPSKPEIVSKALFLETEQLKKLGDCISEDSYPDGNITWYRNGKVL HPLEGAVVIIFKKEMDPVTQLYTMTSTLEYKTTKADIQMPFTCSVTYYGP SGQKTIHSEQAVFDIYYPTEQVTIQVLPPKNAIKEGDNITLKCLGNGNPP PEEFLFYLPGQPEGIRSSNTYTLTDVRRNATGDYKCSLIDKKSMIASTAI TVHYLDLSLNPSGEVTRQIGDALPVSCTISASRNATVVWMKDNIRLRSSP SFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKMTKKTDPS GLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKIIISP EENVTLTCTAENQLERTVNSLNVSAISIPEHDEADEISDENREKVNDQA
      • Predicted molecular weight

        83 kDa including tags
      • Amino acids

        28 to 526
      • Additional sequence information

        Fused with Fc fragment of Human IgG1 at the C-terminus (NP_001618).

    Associated products

    • Related Products

      • Anti-CD166 antibody (ab78649)

    Specifications

    Our Abpromise guarantee covers the use of ab191959 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at 4°C prior to reconstitution. Upon reconsitution add a carrier protein (0.1% BSA). Store at -80°C. Avoid freeze / thaw cycle.

      pH: 7.4
      Constituents: 0.61% Tris, 5% Trehalose, 0.75% Glycine, L-Arginine, Sodium chloride

      Lyophilized from 0.22 µm filtered solution.
      5-10% trehalose is commonly used for freeze drying, and after reconstitution, the trehalose is mostly about 3-5%

    • Reconstitution
      Reconstitute with sterile deionized water to a concentration of 300 µg/ml.

    General Info

    • Alternative names

      • Activated leukocyte cell adhesion molecule
      • ALCAM
      • ALCAM protein
      • CD 166
      • CD166
      • CD166 antigen
      • CD166_HUMAN
      • FLJ3851
      • FLJ38514
      • MEMD
      • MGC71733
      see all
    • Function

      Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.
    • Tissue specificity

      Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines.
    • Sequence similarities

      Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 2 Ig-like V-type (immunoglobulin-like) domains.
    • Domain

      The CD6 binding site is located in the N-terminal Ig-like domain.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession Q13740 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human CD166 protein (Fc Chimera) (ab191959)
      SDS-PAGE - Recombinant Human CD166 protein (Fc Chimera) (ab191959)

      SDS-PAGE analysis of reduced ab191959 stained overnight with Coomassie Blue. DTT-reduced protein migrates as 95-120 kDa due to glycosylation.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab191959? Please let us know so that we can cite the reference in this datasheet.

    ab191959 has not yet been referenced specifically in any publications.

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