Recombinant Human CD172 gamma protein (Fc Chimera) (ab172854)

Product name

Recombinant Human CD172 gamma protein (Fc Chimera)
See all CD172 gamma proteins and peptides
Protein length

Protein fragment

Nature

Recombinant
Source

HEK 293 cells
Amino Acid Sequence
- Accession
  
  Q9P1W8
- Species
  
  Human
- Sequence
  
  GEEELQMIQPEKLLLVTVGKTATLHCTVTSLLPVGPVLWFRGVGPGRELI YNQKEGHFPRVTTVSDLTKRNNMDFSIRISSITPADVGTYYCVKFRKGSP ENVEFKSGPGTEMALGAKPSAPVVLGPAARTTPEHTVSFTCESHGFSPRD ITLKWFKNGNELSDFQTNVDPTGQSVAYSIRSTARVVLDPWDVRSQVICE VAHVTLQGDPLRGTANLSEAIRVPPTLEVTQQPMRVGNQVNVTCQVRKFY PQSLQLTWSENGNVCQRETASTLTENKDGTYNWTSWFLVNISDQRDDVVL TCQVKHDGQLAVSKRLALEVTVHQKDQSSDATPVDDIEGRMDEPKSCDKT HTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKV SNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFY PSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVF SCSVMHEALHNHYTQKSLSLSPGK
- Molecular weight
  
  64 kDa including tags
- Amino acids
  
  28 to 360
- Additional sequence information
  
  Fused with a FC tag at the C-terminus.

Our Abpromise guarantee covers the use of ab172854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications

SDS-PAGE

HPLC
Endotoxin level

1.000 Eu/µg
Purity

>95% by SDS-PAGE .
Purity greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. ab172854 is 0.2 µM filtered.
Form

Liquid
Concentration information loading...

Stability and Storage

Shipped on Dry Ice. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

pH: 7.4
Constituent: 100% PBS

Alternative names
- CD172 antigen like family member B
- bA77C3.1
- CD172 antigen-like family member B
- CD172g
- CD172g antigen
- FLJ42230
- RP11-77C3.2
- Signal regulatory protein beta 2
- Signal regulatory protein gamma
- Signal-regulatory protein beta-2
- Signal-regulatory protein gamma
- SIRP B2
- SIRP beta 2
- SIRP gamma
- SIRP-b2
- SIRP-beta-2
- SIRP-gamma
- SIRPB2
- SIRPG
- SIRPG_HUMAN
- SIRPgamma
see all
Function

Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
Tissue specificity

Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T lymphocytes that have undergone thymic selection.
Sequence similarities

Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Cellular localization

Membrane.
Target information above from: UniProt accession Q9P1W8 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

Datasheet

ab172854 has not yet been referenced specifically in any publications.

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Recombinant Human CD172 gamma protein (Fc Chimera) (ab172854)

Overview

Description

Specifications

Preparation and Storage

General Info

Datasheets and documents

References

Customer reviews and Q&As