The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
B lymphocyte antigen CD20
B Lymphocyte Cell Surface Antigen B1
B-lymphocyte antigen CD20
B-lymphocyte cell-surface antigen B1
B-lymphocyte surface antigen B1
Fc epsilon receptor I beta chain
Fc Fragment of IgE high affinity I receptor for beta polypeptide
High affinity immunoglobulin epsilon receptor subunit beta
IgE Fc receptor subunit beta
leukocyte surface antigen Leu 16
Leukocyte surface antigen Leu-16
Membrane spanning 4 domains A1
Membrane spanning 4 domains subfamily A member 2
Membrane-spanning 4-domains subfamily A member 1
This protein may be involved in the regulation of B-cell activation and proliferation.
Expressed on B-cells.
Involvement in disease
Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
Belongs to the MS4A family.
Phosphorylated. Might be functionally regulated by protein kinase(s).