The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Measured by its ability to bind with HIV-1 gp120 in a functional ELISA.
< 1.000 Eu/µg
% SDS-PAGE. ab167756 is lyophilized from 0.22 µm filtered solution.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.00 Constituents: 5% Trehalose, 0.75% Glycine, 0.61% Tris
This product is an active protein and may elicit a biological response in vivo, handle with caution.
It is recommended to reconstitute the lyophilized protein in sterile deionized water. Solubilise for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage.
CD4 antigen (p55)
CD4+ Lymphocyte deficiency, included
Lymphocyte antigen CD4
T cell antigen T4
T cell antigen T4/LEU3
T cell differentiation antigen L3T4
T cell OKT4 deficiency, included
T cell surface antigen T4/Leu 3
T cell surface antigen T4/Leu3
T cell surface glycoprotein CD4
T-cell surface antigen T4/Leu-3
T-cell surface glycoprotein CD4
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.