The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
< 1.000 Eu/µg
>95% by SDS-PAGE . Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -80°C.
pH: 7.40 Constituent: 100% PBS
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 3X PBS.
Aliquot the reconstituted solution and store at < -20°C.
B cell associated molecule CD40
B cell surface antigen CD40
B cell-associated molecule
B-cell surface antigen CD40
CD40 antigen (TNF receptor superfamily member 5)
CD40 molecule, TNF receptor superfamily member 5
CD40 type II isoform
Nerve growth factor receptor related B lymphocyte activation molecule
TNF receptor superfamily member 5
Tumor necrosis factor receptor superfamily , member 5
Tumor necrosis factor receptor superfamily member 5
Tumor necrosis factor receptor superfamily member 5 precursor
Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a
Receptor for TNFSF5/CD40LG.
B-cells and in primary carcinomas.
Involvement in disease
Defects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3) [MIM:606843]; also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.