Recombinant Human CD42a/GP-IX protein (denatured) (ab139790)

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Description

  • Product name

    Recombinant Human CD42a/GP-IX protein (denatured)

  • Purity

    > 90 % SDS-PAGE.

  • Expression system

    Escherichia coli

  • Accession

    P14770

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSTKDCPSP CTCRALETMG LWVDCRGHGL TALPALPART RHLLLANNSL QSVPPGAFDH LPQLQTLDVT QNPWHCDCSL TYLRLWLEDR TPEALLQVRC ASPSLAAHGP LGRLTGYQLG SCGWQLQASW VRPG

    • Predicted molecular weight

      17 kDa including tags

    • Amino acids

      17 to 147

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab139790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid

  • Additional notes

    Previously labelled as CD42a. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 12.01% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • CD42a
    • Glycoprotein 9
    • Glycoprotein IX
    • Glycoprotein IX (platelet)
    • Glycoprotein IX precursor
    • GP IX
    • GP-IX
    • GP9
    • GPIX
    • GPIX_HUMAN
    • Platelet glycoprotein IX
    see all

  • Function

    The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.

  • Involvement in disease

    Defects in GP9 are a cause of Bernard-Soulier syndrome (BSS) [MIM:231200]; also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency.

  • Sequence similarities

    Contains 1 LRR (leucine-rich) repeat.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.

  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human CD42a/GP-IX protein (denatured) (ab139790)
    SDS-PAGE - Recombinant Human CD42a/GP-IX protein (denatured) (ab139790)
    15% SDS-PAGE analysis of ab139790 (3µg).

References

ab139790 has not yet been referenced specifically in any publications.

Publishing research using ab139790? Please let us know so that we can cite the reference in this datasheet.

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