Recombinant Human CD42a/GP-IX protein (denatured) (ab139790)
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Overview
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Product name
Recombinant Human CD42a/GP-IX protein (denatured)
See all CD42a/GP-IX proteins and peptides -
Protein length
Protein fragment
Description
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Nature
Recombinant -
Source
Escherichia coli -
Amino Acid Sequence
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Accession
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Species
Human -
Sequence
MGSSHHHHHH SSGLVPRGSH MGSTKDCPSP CTCRALETMG LWVDCRGHGL TALPALPART RHLLLANNSL QSVPPGAFDH LPQLQTLDVT QNPWHCDCSL TYLRLWLEDR TPEALLQVRC ASPSLAAHGP LGRLTGYQLG SCGWQLQASW VRPG -
Molecular weight
17 kDa including tags -
Amino acids
17 to 147 -
Tags
His tag N-Terminus
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab139790 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Purity
> 90 % SDS-PAGE. -
Form
Liquid -
Additional notes
Previously labelled as CD42a.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 12.01% Urea, 0.32% Tris HCl, 10% Glycerol
General Info
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Alternative names
- CD42a
- Glycoprotein 9
- Glycoprotein IX
see all -
Function
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. -
Involvement in disease
Defects in GP9 are a cause of Bernard-Soulier syndrome (BSS) [MIM:231200]; also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency. -
Sequence similarities
Contains 1 LRR (leucine-rich) repeat.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain. -
Cellular localization
Membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human CD42a/GP-IX protein (denatured) (ab139790)15% SDS-PAGE analysis of ab139790 (3µg).
Datasheets and documents
References
ab139790 has not yet been referenced specifically in any publications.
