Recombinant Human CD42a/GP-IX protein (denatured) (ab139790)

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SDS-PAGE - Recombinant Human CD42a/GP-IX protein (denatured) (ab139790)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 90% SDS-PAGE
    • Tags: His tag N-Terminus
    • Suitable for: SDS-PAGE

    Description

    • Product name

      Recombinant Human CD42a/GP-IX protein (denatured)

    • Purity

      > 90 % SDS-PAGE.

    • Expression system

      Escherichia coli

    • Accession

      P14770

    • Protein length

      Protein fragment

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MGSSHHHHHH SSGLVPRGSH MGSTKDCPSP CTCRALETMG LWVDCRGHGL TALPALPART RHLLLANNSL QSVPPGAFDH LPQLQTLDVT QNPWHCDCSL TYLRLWLEDR TPEALLQVRC ASPSLAAHGP LGRLTGYQLG SCGWQLQASW VRPG

      • Predicted molecular weight

        17 kDa including tags

      • Amino acids

        17 to 147

      • Tags

        His tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab139790 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Liquid

    • Additional notes

      Previously labelled as CD42a. 

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Constituents: 12.01% Urea, 0.32% Tris HCl, 10% Glycerol (glycerin, glycerine)

    General Info

    • Alternative names

      • CD42a
      • Glycoprotein 9
      • Glycoprotein IX
      • Glycoprotein IX (platelet)
      • Glycoprotein IX precursor
      • GP IX
      • GP-IX
      • GP9
      • GPIX
      • GPIX_HUMAN
      • Platelet glycoprotein IX
      see all

    • Function

      The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.

    • Involvement in disease

      Defects in GP9 are a cause of Bernard-Soulier syndrome (BSS) [MIM:231200]; also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency.

    • Sequence similarities

      Contains 1 LRR (leucine-rich) repeat.
      Contains 1 LRRCT domain.
      Contains 1 LRRNT domain.

    • Cellular localization

      Membrane.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human CD42a/GP-IX protein (denatured) (ab139790)
      SDS-PAGE - Recombinant Human CD42a/GP-IX protein (denatured) (ab139790)
      15% SDS-PAGE analysis of ab139790 (3µg).

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab139790? Please let us know so that we can cite the reference in this datasheet.

    ab139790 has not yet been referenced specifically in any publications.

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