Recombinant Human CD44 protein (ab158063)

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SDS-PAGE - Recombinant Human CD44 protein (ab158063)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: WB, ELISA

    Description

    • Product name

      Recombinant Human CD44 protein
      See all CD44 proteins and peptides

    • Expression system

      Wheat germ

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAA DLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAAN NTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNR DGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFST VHPIPDEDSPWITDSTDRIPATSTSSNTISAGWEPNEENEDERDRHLSFS GSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTR MTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTT EETATQKEQWFGNRWHEGYRQTPREDSHSTTGTAAASAHTSHPMQGRTTP SPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSTTLQPTANPNTGLVE DLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGG RRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGD SNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIR TPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVED RKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV

      • Amino acids

        1 to 699

      • Tags

        GST tag N-Terminus

    Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab158063 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Western blot

      ELISA

    • Form

      Liquid

    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • LHR
      • BA-1
      • CD 44
      • CD44
      • CD44 antigen
      • CD44 molecule
      • CD44 molecule (Indian blood group)
      • CD44_HUMAN
      • CDw44
      • CDW44 antigen
      • Cell surface glycoprotein CD44
      • chondroitin sulfate proteoglycan 8
      • CSPG8
      • ECMR-III
      • Epican
      • Extracellular matrix receptor III
      • GP90 lymphocyte homing/adhesion receptor
      • HCELL
      • hematopoietic cell E- and L-selectin ligand
      • Heparan sulfate proteoglycan
      • Hermes antigen
      • homing function and Indian blood group system
      • HSA
      • HUTCH-I
      • HUTCH1
      • HUTCHI
      • Hyaluronate receptor
      • IN
      • INLU-related p80 Glycoprotein
      • MC56
      • MDU2
      • MDU3
      • MGC10468
      • MIC4
      • MUTCH I
      • MUTCH1
      • PGP-1
      • PGP-I
      • PGP1
      • Phagocytic glycoprotein 1
      • Phagocytic glycoprotein I
      • Soluble CD44
      see all

    • Function

      Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

    • Tissue specificity

      Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

    • Sequence similarities

      Contains 1 Link domain.

    • Domain

      The lectin-like LINK domain is responsible for hyaluronan binding.

    • Post-translational
      modifications

      Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
      N-glycosylated.
      O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s).
      Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.

    • Cellular localization

      Membrane.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human CD44 protein (ab158063)
      SDS-PAGE - Recombinant Human CD44 protein (ab158063)
      ab158063 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab158063? Please let us know so that we can cite the reference in this datasheet.

    ab158063 has not yet been referenced specifically in any publications.

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