Recombinant Human CD68 protein (denatured) (ab134533)

Submit a review Submit a question

Description

  • Product name

    Recombinant Human CD68 protein (denatured)
    See all CD68 proteins and peptides

  • Purity

    > 85 % SDS-PAGE.

  • Expression system

    Escherichia coli

  • Accession

    P34810

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHPLHHHSSGLVPRGSHMGSHMNDCPHKKSATLLPSFTVTPTVTEST GTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSN STATSQGPSTATHSPATTSHGNATVHPTSNSTATSPGFTSSAHPEPPPPS PSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVL NPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSYMAVEYN VSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLR LQAAQLPHTGVFGQSFSCPSDRS

    • Predicted molecular weight

      34 kDa including tags

    • Amino acids

      22 to 319

    • Tags

      His tag N-Terminus

  • Description

    Recombinant Human CD68 protein

Specifications

Our Abpromise guarantee covers the use of ab134533 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 6.01% Urea, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names

    • CD 68
    • CD68
    • CD68 antigen
    • CD68 molecule
    • CD68_HUMAN
    • DKFZp686M18236
    • gp11
    • Gp110
    • LAMP4
    • MACROPHAGE ANTIGEN CD68
    • Macrophage antigen CD68 (microsialin)
    • Macrosialin
    • SCARD1
    • Scavenger receptor class D member 1
    see all

  • Function

    Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

  • Tissue specificity

    Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.

  • Sequence similarities

    Belongs to the LAMP family.

  • Post-translational
    modifications

    N- and O-glycosylated.

  • Cellular localization

    Cell membrane and Endosome membrane. Lysosome membrane.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human CD68 protein (denatured) (ab134533)
    SDS-PAGE - Recombinant Human CD68 protein (denatured) (ab134533)
    15% SDS-PAGE analysis of 3 µg ab134533.

References

ab134533 has not yet been referenced specifically in any publications.

Publishing research using ab134533? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

There are currently no Customer reviews or Questions for ab134533.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com