Recombinant Human CD68 protein (Fc Chimera) (ab174015)
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Overview
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Product nameRecombinant Human CD68 protein (Fc Chimera)
See all CD68 proteins and peptides -
Protein lengthProtein fragment
Description
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NatureRecombinant
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SourceHEK 293 cells
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Amino Acid Sequence
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Accession
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SpeciesHuman
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SequenceNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTTTHRTTTTGTTS HGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNATV HPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVH LQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYG HLSFGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNASLRDLQAPL GQSFSCSNSSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCPSDRS
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Molecular weight59 kDa including tags
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Amino acids22 to 319
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Additional sequence informationFused with Fc fragment of Human IgG1 at the C-terminus.
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Specifications
Our Abpromise guarantee covers the use of ab174015 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Endotoxin level< 0.100 Eu/µg
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Purity> 95 % SDS-PAGE.
ab174015 is lyophilized from 0.22 µm filtered solution. -
FormLyophilised
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at 4°C (stable for up to 12 months). Store at -20°C long term. Avoid freeze / thaw cycle.
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ReconstitutionIt is recommended to reconstitute the lyophilized protein in 100 µl sterile deionized water to a final concentration of 1 mg/ml. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing.
General Info
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Alternative names
- CD 68
- CD68
- CD68 antigen
see all -
FunctionCould play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
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Tissue specificityHighly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
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Sequence similaritiesBelongs to the LAMP family.
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Post-translational
modificationsN- and O-glycosylated. -
Cellular localizationCell membrane and Endosome membrane. Lysosome membrane.
- Information by UniProt
Images
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SDS-PAGE - Recombinant Human CD68 protein (Fc Chimera) (ab174015)Reduced SDS-PAGE analysis of ab174015, stained overnight with Coomassie Blue.
Datasheets and documents
References
ab174015 has not yet been referenced specifically in any publications.
