Recombinant human CD68 protein (Fc Chimera Active) (ab214829)
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Overview
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Product nameRecombinant human CD68 protein (Fc Chimera Active)
See all CD68 proteins and peptides -
Protein lengthProtein fragment
Description
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NatureRecombinant
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SourceCHO cells
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Amino Acid Sequence
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Accession
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SpeciesHuman
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SequenceNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTTTHRTTTTGTTS HGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNATV HPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVH LQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYG HLSFGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNASLRDLQAPL GQSFSCSNSSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCPSDRS
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Amino acids22 to 319
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Additional sequence informationExtracellular domain fused to the N-terminus of the Fc region of Human IgG1.
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab214829 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Biological activity
Measured by its binding ability in a functional ELISA assay.
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Applications
SDS-PAGE
Functional Studies
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Endotoxin level< 0.060 Eu/µg
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Purity>= 98 % SDS-PAGE.
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FormLyophilised
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C long term. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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ReconstitutionReconstitute with 100 µL sterile water. Add 1X PBS to the desired protein concentration. Working aliquots are stable for up to 3 months when stored at -20°C.
General Info
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Alternative names
- CD 68
- CD68
- CD68 antigen
see all -
FunctionCould play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
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Tissue specificityHighly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
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Sequence similaritiesBelongs to the LAMP family.
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Post-translational
modificationsN- and O-glycosylated. -
Cellular localizationCell membrane and Endosome membrane. Lysosome membrane.
- Information by UniProt
Datasheets and documents
References
ab214829 has not yet been referenced specifically in any publications.
