Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMARSEDR YRNPKGSACS RIWQSPRFIA RKRGFTVKMH CYMNSASGNV SWLWKQEMDE NPQQLKLEKG RMEESQNESL ATLTIQGIRF EDNGIYFCQQ KCNNTSEVYQ GCGTELRVMG FSTLAQLKQR NTLKD
    • Molecular weight

      18 kDa including tags
    • Amino acids

      29 to 159
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab137157 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    > 90 % SDS-PAGE.

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 12.01% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • AGM6
    • B cell antigen receptor complex associated protein beta chain
    • B cell specific glycoprotein B29
    • B-cell antigen receptor complex-associated protein beta chain
    • B-cell-specific glycoprotein B29
    • B29
    • B29/Ig-beta/CD79b
    • CD 79b
    • CD79b
    • CD79b antigen
    • CD79b antigen (immunoglobulin associated beta)
    • CD79b molecule
    • CD79b molecule immunoglobulin associated beta
    • CD79b protein
    • CD79B_HUMAN
    • Ig beta
    • Ig-beta
    • IGB
    • Igbeta
    • Immunoglobulin associated B29
    • Immunoglobulin associated B29 protein
    • Immunoglobulin associated beta
    • Immunoglobulin associated protein
    • Immunoglobulin-associated B29 protein
    • MGC108607
    see all
  • Function

    Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
  • Tissue specificity

    B-cells.
  • Involvement in disease

    Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
  • Sequence similarities

    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    Contains 1 ITAM domain.
  • Post-translational
    modifications

    Phosphorylated on tyrosine upon B-cell activation.
  • Cellular localization

    Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab137157 (3µg)

References

ab137157 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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