Recombinant Human CD8 alpha protein (ab114161)

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SDS-PAGE - Recombinant Human CD8 alpha protein (ab114161)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: WB, ELISA, SDS-PAGE

    Description

    • Product name

      Recombinant Human CD8 alpha protein
      See all CD8 alpha proteins and peptides

    • Expression system

      Wheat germ

    • Accession

      P01732

    • Protein length

      Protein fragment

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        SQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQPRGAAASPTFLL YLSQNKPKAAEGLDTQRFSGKRLGDTFVLTLSDFRRENEGYYFCSALSNS IMYFSHFVPV

      • Predicted molecular weight

        38 kDa including tags

      • Amino acids

        22 to 131

      • Tags

        GST tag N-Terminus

    Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab114161 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Western blot

      ELISA

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.3% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • alpha polypeptide (p32)
      • CD_antigen=CD8a
      • CD8
      • CD8 antigen alpha polypeptide
      • CD8 antigen alpha polypeptide (p32)
      • CD8 antigen, alpha polypeptide (p32)
      • CD8a
      • CD8A antigen
      • CD8A molecule
      • CD8A_HUMAN
      • Leu2
      • Leu2 T lymphocyte antigen
      • Ly 2
      • Ly 35
      • Ly B
      • Ly2
      • Ly3
      • Ly35
      • LyB
      • Lyt 2.1 lymphocyte differentiation antigen (AA at 100)
      • LYT3
      • MAL
      • OKT8 T cell antigen
      • OTTHUMP00000160760
      • OTTHUMP00000160764
      • OTTHUMP00000203528
      • OTTHUMP00000203721
      • p32
      • T cell antigen Leu2
      • T cell co receptor
      • T lymphocyte differentiation antigen T8/Leu 2
      • T-cell surface glycoprotein CD8 alpha chain
      • T-cell surface glycoprotein Lyt 2
      • T-lymphocyte differentiation antigen T8/Leu-2
      • T8 T cell antigen
      • T8/Leu-2 T-lymphocyte differentiation antigen
      see all

    • Function

      Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

    • Involvement in disease

      Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

    • Sequence similarities

      Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    • Post-translational
      modifications

      All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.

    • Cellular localization

      Secreted and Cell membrane.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human CD8 alpha protein (ab114161)
      SDS-PAGE - Recombinant Human CD8 alpha protein (ab114161)
      12.5% SDS-PAGE analysis of ab114161, stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab114161? Please let us know so that we can cite the reference in this datasheet.

    ab114161 has not yet been referenced specifically in any publications.

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