Recombinant Human CD8 alpha protein (ab114161)

Submit a review Submit a question

Description

  • Product name

    Recombinant Human CD8 alpha protein
    See all CD8 alpha proteins and peptides

  • Expression system

    Wheat germ

  • Accession

    P01732

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      SQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQPRGAAASPTFLL YLSQNKPKAAEGLDTQRFSGKRLGDTFVLTLSDFRRENEGYYFCSALSNS IMYFSHFVPV

    • Predicted molecular weight

      38 kDa including tags

    • Amino acids

      22 to 131

    • Tags

      GST tag N-Terminus

Associated products

Specifications

Our Abpromise guarantee covers the use of ab114161 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • Form

    Liquid

  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
    ab114161 is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • alpha polypeptide (p32)
    • CD8
    • CD8 antigen alpha polypeptide
    • CD8 antigen alpha polypeptide (p32)
    • CD8a
    • CD8A antigen
    • CD8A molecule
    • CD8A_HUMAN
    • Leu2
    • Leu2 T lymphocyte antigen
    • Ly3
    • LYT3
    • MAL
    • OKT8 T cell antigen
    • OTTHUMP00000160760
    • OTTHUMP00000160764
    • OTTHUMP00000203528
    • OTTHUMP00000203721
    • p32
    • T cell antigen Leu2
    • T cell co receptor
    • T-cell surface glycoprotein CD8 alpha chain
    • T-lymphocyte differentiation antigen T8/Leu-2
    • T8 T cell antigen
    • T8/Leu-2 T-lymphocyte differentiation antigen
    see all

  • Function

    Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

  • Involvement in disease

    Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

  • Sequence similarities

    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

  • Post-translational
    modifications

    All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.

  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human CD8 alpha protein (ab114161)
    SDS-PAGE - Recombinant Human CD8 alpha protein (ab114161)
    12.5% SDS-PAGE analysis of ab114161, stained with Coomassie Blue.

References

ab114161 has not yet been referenced specifically in any publications.

Publishing research using ab114161? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

There are currently no Customer reviews or Questions for ab114161.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up