Recombinant human CD8 alpha protein (Active) (ab242436)

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Description

  • Product name

    Recombinant human CD8 alpha protein (Active)
    See all CD8 alpha proteins and peptides

  • Biological activity

    Determined by its ability to induce plate adhesion of PHA-stimulated Jurkat cells.

  • Purity

    > 95 % SDS-PAGE.
    Greater than 95% by SDS-PAGE gel and HPLC analyses. Due to glycosylation, it migrates at an apparent molecular weight of approximately 27-29 kDa by SDS-PAGE analysis, under reducing conditions.

  • Expression system

    CHO cells

  • Accession

    P01732

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      SQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQPRGAAASPTFLL YLSQNKPKAAEGLDTQRFSGKRLGDTFVLTLSDFRRENEGYYFCSALSNS IMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGA VHTRGLDFACD

    • Predicted molecular weight

      18 kDa

    • Amino acids

      22 to 182

    • Additional sequence information

      Extracellular domain.

Specifications

Our Abpromise guarantee covers the use of ab242436 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    HPLC

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.50
    Constituent: 0.16% Sodium phosphate

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute in water to 0.1-1.0 mg/ml.

General Info

  • Alternative names

    • alpha polypeptide (p32)
    • CD8
    • CD8 antigen alpha polypeptide
    • CD8 antigen alpha polypeptide (p32)
    • CD8a
    • CD8A antigen
    • CD8A molecule
    • CD8A_HUMAN
    • Leu2
    • Leu2 T lymphocyte antigen
    • Ly3
    • LYT3
    • MAL
    • OKT8 T cell antigen
    • OTTHUMP00000160760
    • OTTHUMP00000160764
    • OTTHUMP00000203528
    • OTTHUMP00000203721
    • p32
    • T cell antigen Leu2
    • T cell co receptor
    • T-cell surface glycoprotein CD8 alpha chain
    • T-lymphocyte differentiation antigen T8/Leu-2
    • T8 T cell antigen
    • T8/Leu-2 T-lymphocyte differentiation antigen
    see all

  • Function

    Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

  • Involvement in disease

    Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

  • Sequence similarities

    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

  • Post-translational
    modifications

    All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.

  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt

References

ab242436 has not yet been referenced specifically in any publications.

Publishing research using ab242436? Please let us know so that we can cite the reference in this datasheet.

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