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    recombinant-human-cd8-alpha-protein-active-ab242436.pdf

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Immunology Adaptive Immunity T Cells Cytotoxic Cells
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Recombinant human CD8 alpha protein (Active) (ab242436)

  • Datasheet
  • SDS
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Key features and details

  • Expression system: CHO cells
  • Purity: > 95% SDS-PAGE
  • Active: Yes
  • Suitable for: Functional Studies, HPLC, SDS-PAGE

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Description

  • Product name

    Recombinant human CD8 alpha protein (Active)
    See all CD8 alpha proteins and peptides
  • Biological activity

    Determined by its ability to induce plate adhesion of PHA-stimulated Jurkat cells.

  • Purity

    > 95 % SDS-PAGE.
    Greater than 95% by SDS-PAGE gel and HPLC analyses. Due to glycosylation, it migrates at an apparent molecular weight of approximately 27-29 kDa by SDS-PAGE analysis, under reducing conditions.
  • Expression system

    CHO cells
  • Accession

    P01732
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      SQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQPRGAAASPTFLL YLSQNKPKAAEGLDTQRFSGKRLGDTFVLTLSDFRRENEGYYFCSALSNS IMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGA VHTRGLDFACD
    • Predicted molecular weight

      18 kDa
    • Amino acids

      22 to 182
    • Additional sequence information

      Extracellular domain.

Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab242436 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Functional Studies

      HPLC

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      Constituent: 0.16% Sodium phosphate

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • Reconstitution
      Reconstitute in water to 0.1-1.0 mg/ml.

    General Info

    • Alternative names

      • alpha polypeptide (p32)
      • CD_antigen=CD8a
      • CD8
      • CD8 antigen alpha polypeptide
      • CD8 antigen alpha polypeptide (p32)
      • CD8 antigen, alpha polypeptide (p32)
      • CD8a
      • CD8A antigen
      • CD8A molecule
      • CD8A_HUMAN
      • Leu2
      • Leu2 T lymphocyte antigen
      • Ly 2
      • Ly 35
      • Ly B
      • Ly2
      • Ly3
      • Ly35
      • LyB
      • Lyt 2.1 lymphocyte differentiation antigen (AA at 100)
      • LYT3
      • MAL
      • OKT8 T cell antigen
      • OTTHUMP00000160760
      • OTTHUMP00000160764
      • OTTHUMP00000203528
      • OTTHUMP00000203721
      • p32
      • T cell antigen Leu2
      • T cell co receptor
      • T lymphocyte differentiation antigen T8/Leu 2
      • T-cell surface glycoprotein CD8 alpha chain
      • T-cell surface glycoprotein Lyt 2
      • T-lymphocyte differentiation antigen T8/Leu-2
      • T8 T cell antigen
      • T8/Leu-2 T-lymphocyte differentiation antigen
      see all
    • Function

      Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
    • Involvement in disease

      Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
    • Sequence similarities

      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • Post-translational
      modifications

      All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.
    • Cellular localization

      Secreted and Cell membrane.
    • Target information above from: UniProt accession P01732 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab242436? Please let us know so that we can cite the reference in this datasheet.

    ab242436 has not yet been referenced specifically in any publications.

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