Recombinant Human CD8 beta protein (ab152059)

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Key features and details

  • Expression system: HEK 293 cells
  • Purity: > 95% SDS-PAGE
  • Endotoxin level: < 1.000 Eu/µg
  • Tags: His tag C-Terminus
  • Suitable for: SDS-PAGE, HPLC

Description

  • Product name

    Recombinant Human CD8 beta protein
    See all CD8 beta proteins and peptides

  • Purity

    > 95 % SDS-PAGE.
    Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

  • Endotoxin level

    < 1.000 Eu/µg

  • Expression system

    HEK 293 cells

  • Accession

    P10966

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLA LWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGS PELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPV DHHHHHH

    • Predicted molecular weight

      18 kDa including tags

    • Amino acids

      22 to 170

    • Tags

      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab152059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    HPLC

  • Form

    Lyophilized
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.

    pH: 7.4
    Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

  • Reconstitution
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in 1X PBS. It is not recommended to reconstitute to a concentration less than 100 µg/ml.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days. For long term storage aliquot and store at < -20°C.

General Info

  • Alternative names

    • CD8b antigen
    • CD_antigen=CD8b
    • CD8 antigen 37 kDa chain
    • CD8 antigen beta polypeptide 1
    • CD8 antigen beta polypeptide 1 (p37)
    • CD8 antigen, beta chain
    • CD8 antigen, beta polypeptide 1
    • CD8 antigen, beta polypeptide 1 (p37)
    • CD8 beta
    • CD8b
    • CD8b molecule
    • CD8B_HUMAN
    • CD8B1
    • Flags: Precursor
    • Leu2
    • Ly3
    • LYT3
    • MGC119115
    • OTTHUMP00000160762
    • OTTHUMP00000160763
    • OX 8 membrane antigen
    • P37
    • T cell surface glycoprotein CD8
    • T cell surface glycoprotein CD8 beta chain
    • T lymphocyte surface glycoprotein beta chain
    • T-cell surface glycoprotein CD8 beta chain
    see all

  • Function

    Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.

  • Tissue specificity

    Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.

  • Sequence similarities

    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

  • Post-translational
    modifications

    Phosphorylated as a consequence of T-cell activation.

  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab152059? Please let us know so that we can cite the reference in this datasheet.

ab152059 has not yet been referenced specifically in any publications.

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