Recombinant Human CD8 beta protein (denatured) (ab177613)

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Description

  • Product name

    Recombinant Human CD8 beta protein (denatured)
    See all CD8 beta proteins and peptides

  • Purity

    > 80 % SDS-PAGE.

  • Expression system

    Escherichia coli

  • Accession

    P10966

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHHSSGLVPRGSHMGSLQQTPAYIKVQTNKMVMLSCEAKISLS NMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASR FILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKS TLKKRVCRLPRPETQKGPLCSP

    • Predicted molecular weight

      19 kDa including tags

    • Amino acids

      22 to 170

    • Tags

      His tag N-Terminus

    • Additional sequence information

      NP_004922 (Extracellular domain).

Specifications

Our Abpromise guarantee covers the use of ab177613 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 2.4% Urea, 10% Glycerol

General Info

  • Alternative names

    • CD8b antigen
    • CD_antigen=CD8b
    • CD8 antigen 37 kDa chain
    • CD8 antigen beta polypeptide 1
    • CD8 antigen beta polypeptide 1 (p37)
    • CD8 antigen, beta chain
    • CD8 antigen, beta polypeptide 1
    • CD8 antigen, beta polypeptide 1 (p37)
    • CD8 beta
    • CD8b
    • CD8b molecule
    • CD8B_HUMAN
    • CD8B1
    • Flags: Precursor
    • Leu2
    • Ly3
    • LYT3
    • MGC119115
    • OTTHUMP00000160762
    • OTTHUMP00000160763
    • OX 8 membrane antigen
    • P37
    • T cell surface glycoprotein CD8
    • T cell surface glycoprotein CD8 beta chain
    • T lymphocyte surface glycoprotein beta chain
    • T-cell surface glycoprotein CD8 beta chain
    see all

  • Function

    Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.

  • Tissue specificity

    Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.

  • Sequence similarities

    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

  • Post-translational
    modifications

    Phosphorylated as a consequence of T-cell activation.

  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human CD8 beta protein (denatured) (ab177613)
    SDS-PAGE - Recombinant Human CD8 beta protein (denatured) (ab177613)

    15% SDS-PAGE analysis of ab177613 (3µg).

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References

Publishing research using ab177613? Please let us know so that we can cite the reference in this datasheet.

ab177613 has not yet been referenced specifically in any publications.

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