Overview

  • Product name

    Recombinant Human CDK11/CDC2L2/CDK11A protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      92 kDa including tags
    • Amino acids

      1 to 783

Specifications

Our Abpromise guarantee covers the use of ab126905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names

    • CD11A_HUMAN
    • CDC2L2
    • CDC2L3
    • CDK11
    • CDK11 p110
    • CDK11 p46
    • CDK11 p58
    • CDK11A
    • Cell division cycle 2 like 2 (PITSLRE proteins)
    • Cell division cycle 2-like protein kinase 2
    • Cell division protein kinase 11A
    • Cyclin-dependent kinase 11A
    • Galactosyltransferase-associated protein kinase p58/GTA
    • p58GTA
    • PITSLRE
    • PITSLRE B
    • PITSLRE protein kinase beta
    • PITSLRE serine/threonine-protein kinase CDC2L2
    • PITSLREB
    see all
  • Function

    Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
  • Tissue specificity

    Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt

Images

  • SDS-PAGE showing ab126905

References

ab126905 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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