This product is an active protein and may elicit a biological response in vivo, handle with caution.
Cell division protein kinase 2
Cyclin dependent kinase 2
p33 protein kinase
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation.
Cyclin A2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
Functional Studies - Recombinant human CDK2 + Cyclin A2 protein (ab51407)
Kinase activity assay. Specific activity 915 nmol/min/mg.
SDS-PAGE - Recombinant human CDK2 + Cyclin A2 protein (ab51407)
Purity determined to be > 70% by densitometry. CDK2 molecular weight 58 kDa
Cyclin A2 molecular weight 78 kDa
This product has been referenced in:
Kitagawa K et al. Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development. Mol Cell Biol34:2732-44 (2014).
Read more (PubMed: 24820417) »