This product is an active protein and may elicit a biological response in vivo, handle with caution.
Cell division kinase 3
Cell division protein kinase 3
Cyclin dependent kinase 3
G1/S specific cyclin E
G1/S specific cyclin E1
CDK3 is a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.
CCNE1 (Cyclin E) is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Functional Studies - CDK3 + CCNE1 protein (Active) (ab85643)
The Specific activity of ab85643 was determined to be 20 nmol/min/mg.
SDS-PAGE - CDK3 + CCNE1 protein (Active) (ab85643)
SDS-PAGE showing ab85643 at approximately 60kDa (CDK3) and 73kDa (CCNE1).
has not yet been referenced specifically in any publications.
Publishing research using ab85643? Please let us know so that we can cite the reference in this datasheet.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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