Recombinant Human CDKL5 protein (ab131695)
- Datasheet
- References
- Protocols
Overview
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Product nameRecombinant Human CDKL5 protein
See all CDKL5 proteins and peptides -
Protein lengthProtein fragment
Description
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NatureRecombinant
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SourceBaculovirus infected Sf9 cells
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Amino Acid Sequence
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Accession
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SpeciesHuman
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Molecular weight84 kDa including tags
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Amino acids1 to 498
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Specifications
Our Abpromise guarantee covers the use of ab131695 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
Western blot
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Purity> 90 % SDS-PAGE.
Assessed by densitometry. -
FormLiquid
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.50
Constituents: 0.31% Glutathione, 0.002% PMSF, 0.005% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.29% Sodium chloride
General Info
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Alternative names
- Cdkl5
- CDKL5_HUMAN
- Cyclin dependent kinase 5 transcript
see all -
FunctionMediates phosphorylation of MECP2.
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Tissue specificityExpressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis.
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Involvement in diseaseNote=Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures and spams and psychomotor impairment. Translocation t(X;6)(p22.3;q14); translocation t(X;7)(p22.3;p15).
Defects in CDKL5 are a cause of epileptic encephalopathy early infantile type 2 (EIEE2) [MIM:300672]; also known as atypical CDKL5-related Rett syndrome. EIEE2 is a severe form of epilepsy characterized by seizures or spasms beginning in infancy. Patients manifest features resembling Rett syndrome such as microcephaly, lack of speech development, stereotypic hand movements. -
Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain. -
Post-translational
modificationsAutophosphorylated. -
Cellular localizationNucleus.
- Information by UniProt
Images
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SDS-PAGE - Recombinant Human CDKL5 protein (ab131695)The purity of ab131695 was determined to be >90% by densitometry.
Datasheets and documents
References
ab131695 has not yet been referenced specifically in any publications.
