Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      19 kDa
    • Amino acids

      25 to 187

Specifications

Our Abpromise guarantee covers the use of ab129133 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    Determined by its ability to stimulate the proliferation of Rat C6 cells. The expected ED50 for this effect is 15-25 µg/ml.
  • Applications

    Functional Studies

    SDS-PAGE

    HPLC

  • Purity

    > 98 % SDS-PAGE.
    Purity: > 98% by SDS-PAGE and HPLC analysis.
  • Form

    Lyophilised
  • Additional notes

    Endotoxin level: < 0.1 ng/µg of Human CDNF. Please note: always centrifuge product before opening vial.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Upon reconstitution ab129133 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.

General Info

  • Alternative names

    • Arginine rich mutated in early stage tumors like 1
    • ARMET L1
    • ARMET like protein 1
    • ARMET-like protein 1
    • ARMETL 1
    • ARMETL1
    • CDNF
    • CDNF_HUMAN
    • Cerebral dopamine neurotrophic factor
    • Conserved dopamine neurotrophic factor
    see all
  • Function

    Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra.
  • Tissue specificity

    Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum.
  • Sequence similarities

    Belongs to the ARMET family.
  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab129133 has not yet been referenced specifically in any publications.

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