Recombinant Human CEACAM3 protein (ab151918)

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Description

  • Product name

    Recombinant Human CEACAM3 protein

  • Purity

    > 95 % SDS-PAGE.
    Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

  • Endotoxin level

    < 1.000 Eu/µg

  • Expression system

    HEK 293 cells

  • Accession

    P40198

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      KLTIESMPLSVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNSLIVGYVI GTQQATPGAAYSGRETIYTNASLLIQNVTQNDIGFYTLQVIKSDLVNEEA TGQFHVYQENAPGLPVGAVAGVDHHHHHH

    • Predicted molecular weight

      14 kDa including tags

    • Amino acids

      35 to 155

    • Tags

      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab151918 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    HPLC

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.

    pH: 7.20
    Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

  • Reconstitution
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in 1X PBS. It is not recommended to reconstitute to a concentration less than 100 µg/ml.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days. For long term storage aliquot and store at < -20°C.

General Info

  • Alternative names

    • carcinoembryonic
    • Carcinoembryonic antigen CGM1
    • Carcinoembryonic antigen gene family member 1
    • carcinoembryonic antigen related cell adhesion molecule 3
    • Carcinoembryonic antigen-related cell adhesion molecule 3
    • cd66 d
    • CD66d
    • CD66d antigen
    • CEA
    • CEACAM 3
    • CEACAM-3
    • Ceacam3
    • CEAM 3
    • CEAM-3
    • CEAM3
    • CEAM3_HUMAN
    • CGM1
    • Nonspecific cross reacting antigen
    • W264
    • W282
    see all

  • Function

    Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.

  • Tissue specificity

    CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney.

  • Sequence similarities

    Belongs to the immunoglobulin superfamily. CEA family.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

  • Domain

    The cytosolic domain is involved in S100A9 interaction.

  • Post-translational
    modifications

    Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.

  • Cellular localization

    Membrane.
  • Information by UniProt

References

ab151918 has not yet been referenced specifically in any publications.

Publishing research using ab151918? Please let us know so that we can cite the reference in this datasheet.

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