Overview

  • Product name

    Recombinant Human CHL1 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      26 kDa
    • Amino acids

      788 to 1025
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127358 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • CALL
    • Cell adhesion molecule with homology to L1CAM
    • Cell adhesion molecule with homology to L1CAM (close homolog of L1)
    • Cell adhesion molecule with homology to L1CAM (close homologue of L1)
    • Close homolog of L1
    • FLJ44930
    • L1 cell adhesion molecule 2
    • L1CAM2
    • MGC132578
    • Neural cell adhesion molecule
    see all
  • Relevance

    CHL1 is an extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. CHL1 plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. CHL1 may play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins and recruits ANK3 to the plasma membrane.
  • Cellular localization

    Cell Membrane and Secreted

References

ab127358 has not yet been referenced specifically in any publications.

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