The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Chloride channel protein 5
Chloride channel voltage sensitive 5
Chloride transporter ClC-5
H(+)/Cl(-) exchange transporter 5
Voltage gated chloride ion channel CLCN5
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle.
Involvement in disease
Hypophosphatemic rickets, X-linked recessive Nephrolithiasis 2 Nephrolithiasis 1 Low molecular weight proteinuria with hypercalciuria and nephrocalcinosis
Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily. Contains 2 CBS domains.
Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation.