Description

  • Product name

    Recombinant Human CHMP1B protein
  • Purity

    > 85 % SDS-PAGE.
    ab126679 is purified by using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMSNMEK HLFNLKFAAK ELSRSAKKCD KEEKAEKAKI KKAIQKGNME VARIHAENAI RQKNQAVNFL RMSARVDAVA ARVQTAVTMG KVTKSMAGVV KSMDATLKTM NLEKISALMD KFEHQFETLD VQTQQMEDTM SSTTTLTTPQ NQVDMLLQEM ADEAGLDLNM ELPQGQTGSV TSVASAEQD ELSQRLARLR DQV
    • Predicted molecular weight

      25 kDa including tags
    • Amino acids

      1 to 199
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab126679 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names

    • 2810405I11Rik
    • C10orf2
    • C18 ORF2
    • C18orf2
    • Charged multivesicular body protein 1b
    • CHM1B_HUMAN
    • CHMP family, member 1B
    • CHMP1.5
    • CHMP1b
    • Choromosome 18 open reading frame 2
    • Chromatin-modifying protein 1b
    • hVps46-2
    • vacuolar protein sorting 46-2
    • Vacuolar protein sorting-associated protein 46-2
    • Vps46-2
    • Vps46B
    see all
  • Function

    Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release.
  • Tissue specificity

    Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta and brain.
  • Sequence similarities

    Belongs to the SNF7 family.
  • Cellular localization

    Cytoplasm > cytosol. Endosome. Late endosome membrane. Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab126679 (3 µg). Please note: Molecular weight on SDS-PAGE will appear higher.

References

ab126679 has not yet been referenced specifically in any publications.

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