Overview

  • Product name

    Recombinant Human Cip4 protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLV KKYLPKRPAKDDPESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCL ELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEK AAQTAERLDQDINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRD QAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLE GMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFSQPMNRAPSDSSL GTPSDGRPELRGPGRSRTKRWPFGKKNKTVVTEDFSHLPPEQQRKRLQQQ LEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAETLSNIER LKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSAS QDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEGSSE GTISMAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYLRVTLN
    • Molecular weight

      89 kDa including tags
    • Amino acids

      1 to 545

Associated products

Specifications

Our Abpromise guarantee covers the use of ab132255 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 µ/µl.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • Cdc42 interacting protein 4
    • Cdc42 interaction protein 4 long isoform
    • Cdc42-interacting protein 4
    • CG11341
    • CG15015 PA
    • Cip 4
    • CIP4
    • CIP4_HUMAN
    • DCIP4
    • hSTP
    • Protein Felic
    • Salt tolerant protein
    • Salt tolerator
    • STOT
    • STP
    • Thyroid hormone receptor interactor 10
    • Thyroid receptor interacting protein 10
    • Thyroid receptor-interacting protein 10
    • TR-interacting protein 10
    • TRIP 10
    • TRIP-10
    • trip10
    • Truncated Cdc42 interaction protein 4
    see all
  • Function

    Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
  • Tissue specificity

    Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.
  • Sequence similarities

    Belongs to the FNBP1 family.
    Contains 1 FCH domain.
    Contains 1 REM (Hr1) repeat.
    Contains 1 SH3 domain.
  • Post-translational
    modifications

    Tyrosine phosphorylated. Also phosphorylated by PKA.
  • Cellular localization

    Cytoplasm > perinuclear region and Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection > phagocytic cup. Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9.
  • Information by UniProt

Images

  • ab132255 analyzed by 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab132255 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab132255.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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