Description

  • Product name

    Recombinant Human CLEC-2 protein (denatured)
    See all CLEC-2 proteins and peptides
  • Purity

    > 90 % SDS-PAGE.
    ab202622 was purified by conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSSVMQRNY LQGENENRTG TLQQLAKRFC QYVVKQSELK GTFKGHKCSP CDTNWRYYGD SCYGFFRHNL TWEESKQYCT DMNATLLKID NRNIVEYIKA RTHLIRWVGL SRQKSNEVWK WEDGSVISEN MFEFLEDGKG NMNCAYFHNG KMHPTFCENK HYLMCERKAG MTKVDQLP
    • Predicted molecular weight

      23 kDa including tags
    • Amino acids

      55 to 229
    • Tags

      His tag N-Terminus
    • Additional sequence information

      NP_057593

Specifications

Our Abpromise guarantee covers the use of ab202622 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.0
    Constituents: 10% Glycerol, 0.24% Tris buffer

General Info

  • Alternative names

    • 1810061I13Rik
    • C type lectin domain family 1 member B
    • C type lectin like receptor 2
    • C-type lectin domain family 1 member B
    • C-type lectin domain family 1, member B
    • C-type lectin-like receptor 2
    • C-type lectin-like receptor-2
    • CLC1B_HUMAN
    • CLEC 2
    • CLEC 2B
    • CLEC-2
    • CLEC1B
    • CLEC2
    • CLEC2B
    • PRO1384
    • QDED721
    see all
  • Function

    Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.
  • Tissue specificity

    Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.
  • Sequence similarities

    Contains 1 C-type lectin domain.
  • Post-translational
    modifications

    Glycosylated.
    Phosphorylated on tyrosine residue in response to rhodocytin binding.
  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab202622 (3 µg)

References

ab202622 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab202622.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up