Description

  • Product name

    Recombinant Human CLNS1A/CLCI protein
  • Purity

    > 90 % SDS-PAGE.
    ab137159 was purified using conventional chromatography.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMSFLKS FPPPGPAEGL LRQQPDTEAV LNGKGLGTGT LYIAESRLSW LDGSGLGFSL EYPTISLHAL SRDRSDCLGE HLYVMVNAKF EEESKEPVAD EEEEDSDDDV EPITEFRFVP SDKSALEAMF TAMCECQALH PDPEDEDSDD YDGEEYDVEA HEQGQGDIPT FYTYEEGLSH LTAEGQATLE RLEGMLSQSV SSQYNMAGVR TEDSIRDYED GMEVDTTPTV AGQFEDADVD H
    • Predicted molecular weight

      29 kDa including tags
    • Amino acids

      1 to 237
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab137159 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Additional notes

     This product was previously labelled as CLNS1A

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.003% DTT, 0.32% Tris HCl, 10% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names

    • Chloride channel
    • Chloride channel nucleotide sensitive 1A
    • Chloride channel regulatory protein
    • Chloride conductance regulator, volume sensitive
    • Chloride conductance regulatory protein ICln
    • Chloride ion current inducer protein
    • ClCI
    • CLNS 1A
    • Clns1a
    • CLNS1B
    • I(Cln)
    • ICln
    • ICLN_HUMAN
    • Methylosome subunit pICln
    • nucleotide sensitive 1A
    • Reticulocyte pICln
    • Reticulocyte protein ICln
    see all
  • Function

    The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.
  • Sequence similarities

    Belongs to the pICln family.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cytoplasm. Nucleus. Cytoplasm > cytoskeleton. A small fraction is also associated with the cytoskeleton.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab137159 (3µg)

References

ab137159 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab137159.
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