Description

  • Product name

    Recombinant Human CMAS protein
  • Expression system

    Wheat germ
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MDSVEKGAATSVSNPRGRPSRGRPPKLQRNSRGGQGRGVEKPPHLAALIL ARGGSKGIPLKNIKHLAGVPLIGWVLRAALDSGAFQSVWVSTDHDEIENV AKQFGAQVHRRSSEVSKDSSTSLDAIIEFLNYHNEVDIVGNIQATSPCLH PTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAK RPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDV DIDWPIAEQRVLR
    • Amino acids

      1 to 263
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab163270 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • CMAS
    • CMP N acetylneuraminic acid synthase
    • CMP Neu5Ac synthetase
    • CMP NeuNAc synthetase
    • CMP sialic acid synthetase
    • CMP-N-acetylneuraminic acid synthase
    • CMP-N-acetylneuraminic acid synthetase
    • CMP-NeuNAc synthase
    • CSS
    • Cytidine 5' monophosphate N acetylneuraminic acid synthetase
    • Cytidine 5-prime-monophosphate N-acetylneuraminic acid synthetase
    • Cytidine monophosphate N acetylneuraminic acid synthetase
    • N acylneuraminate cytidylyltransferase
    • N-acylneuraminate cytidylyltransferase
    • NEUA_HUMAN
    see all
  • Function

    Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
  • Tissue specificity

    Ubiquitously expressed. Expressed in pancreas, kidney, liver, skeletal muscle, lung, placenta, brain, heart, colon, PBL, small intestine, ovary, testis, prostate, thymus and spleen.
  • Pathway

    Amino-sugar metabolism; N-acetylneuraminate metabolism.
  • Sequence similarities

    Belongs to the CMP-NeuNAc synthase family.
  • Domain

    The BC2 (basic cluster 2) motif is necessary and sufficient for the nuclear localization and contains the catalytic active site. The localization in the nucleus is however not required for the enzyme activity.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • ab163270 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab163270 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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