Recombinant Human CMT2 protein (ab123183)

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Overview

  • Product name

    Recombinant Human CMT2 protein

  • Protein length

    Full length protein

Description

  • Nature

    Recombinant

  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
      Q15013

    • Species

      Human

    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMAAPEA EVLSSAAVPD LEWYEKSEET HASQIELLET SSTQEPLNAS EAFCPRDCMV PVVFPGPVSQ EGCCQFTCEL LKHIMYQRQQ LPLPYEQLKH FYRKPSPQAE EMLKKKPRAT TEVSSRKCQQ ALAELESVLS HLEDFFARTL VPRVLILLGG NALSPKEFYE LDLSLLAPYS VDQSLSTAAC LRRLFRAIFM ADAFSELQAP PLMGTVVMAQ GHRNCGEDWF RPKLNYRVPS RGHKLTVTLS CGRPSIRTTA WEDYIWFQAP VTFKGFRE

    • Molecular weight

      34 kDa including tags

    • Amino acids

      1 to 274

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab123183 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF

  • Purity

    > 90 % SDS-PAGE.
    ab123183 was purified using conventional chromatography techniques.

  • Form

    Liquid

  • Additional notes

     This product was previously labelled as MAD2L1 binding protein

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names

    • Caught by MAD2 protein
    • CMT2
    • dJ261G23.1
    • KIAA0110
    • MAD2L1 binding protein
    • MAD2L1 binding protein isoform 2
    • MAD2L1-binding protein
    • Mad2l1bp
    • MD2BP_HUMAN
    • MGC11282
    • OTTHUMP00000016496
    • RP1 261G23.6
    see all

  • Function

    May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.

  • Sequence similarities

    Belongs to the MAD2L1BP family.

  • Developmental stage

    During the cell cycle, levels increase and then remain constant until late mitosis after which they drop.

  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.

  • Cellular localization

    Nucleus. Cytoplasm > cytoskeleton > spindle. During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human CMT2 protein (ab123183)
    SDS-PAGE - Recombinant Human CMT2 protein (ab123183)
    15% SDS-PAGE showing ab123183 (3µg). (Molecular size on SDS-PAGE will appear higher than predicted)

References

ab123183 has not yet been referenced specifically in any publications.

Publishing research using ab123183? Please let us know so that we can cite the reference in this datasheet.

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