Overview

  • Product name

    Recombinant Human CNBP protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMSSNECF KCGRSGHWAR ECPTGGGRGR GMRSRGRGFQ FVSSSLPDIC YRCGESGHLA KDCDLQEDAC YNCGRGGHIA KDCKEPKRER EQCCYNCGKP GHLARDCDHA DEQKCYSCGE FGHIQKDCTK VKCYRCGETG HVAINCSKTS EVNCYRCGES GHLARECTIE ATA
    • Molecular weight

      21 kDa including tags
    • Amino acids

      1 to 170
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab140548 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF
  • Purity

    > 90 % SDS-PAGE.
    ab140548 is purified using conventional chromatography techniques.
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.50
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol, 1.17% Sodium chloride

General Info

  • Alternative names

    • CCHC type zinc finger nucleic acid binding protein
    • Cellular nucleic acid binding protein
    • Cellular nucleic acid-binding protein
    • CNBP
    • CNBP_HUMAN
    • CNBP1
    • DM2
    • Erythroid differentiation related
    • PROMM
    • Proximal myotonic myopathy nucleic acid binding protein
    • RNF163
    • Sterol regulatory element binding protein
    • ZCCHC22
    • Zinc finger protein 273
    • Zinc finger protein 9
    • Zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)
    • ZNF9
    see all
  • Function

    Single stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.
  • Tissue specificity

    Present in all tissues examined.
  • Involvement in disease

    Defects in CNBP are the cause of dystrophia myotonica type 2 (DM2) [MIM:602668]; also known as proximal myotonic myopathy (PROMM). A multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases. Note=The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene.
  • Sequence similarities

    Contains 7 CCHC-type zinc fingers.
  • Cellular localization

    Cytoplasm. Endoplasmic reticulum.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis ab140548 (3µg).

References

ab140548 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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