Description

  • Product name

    Recombinant Human Cofilin protein
    See all Cofilin proteins and peptides
  • Purity

    > 95 % SDS-PAGE.
    purified by using conventional chromatography techniques
  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE EGKEILVGDV GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS KDAIKKKLTG IKHELQANCY EEVKDRCTLA EKLGGSAVIS LEGKPL

Specifications

Our Abpromise guarantee covers the use of ab62958 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.242% Tris, 10% Glycerol

General Info

  • Alternative names

    • 18 kDa phosphoprotein
    • CFL
    • CFL 1
    • CFL1
    • COF1_HUMAN
    • Cofilin
    • Cofilin 1
    • Cofilin 1 non muscle
    • Cofilin non muscle isoform
    • Cofilin-1
    • epididymis secretory protein Li 15
    • HEL-S-15
    • non-muscle isoform
    • p18
    see all
  • Function

    Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
  • Tissue specificity

    Widely distributed in various tissues.
  • Sequence similarities

    Belongs to the actin-binding proteins ADF family.
    Contains 1 ADF-H domain.
  • Post-translational
    modifications

    Phosphorylated on Ser-3 in resting cells.
  • Cellular localization

    Nucleus matrix. Cytoplasm > cytoskeleton. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
  • Information by UniProt

Images

  • SDS Page analysis of ab62958 (3ug, 15% gel).

References

ab62958 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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