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    recombinant-human-connexin-32--gjb1-protein-ab158522.pdf

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Recombinant Human Connexin 32 / GJB1 protein (ab158522)

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SDS-PAGE - Recombinant Human Connexin 32 / GJB1 protein (ab158522)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

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    Description

    • Product name

      Recombinant Human Connexin 32 / GJB1 protein
    • Expression system

      Wheat germ
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSS FICNTLQPGCNSVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQQH IEKKMLRLEGHGDPLHLEEVKRHKVHISGTLWWTYVISVVFRLLFEAVFM YVFYLLYPGYAMVRLVKCDVYPCPNTVDCFVSRPTEKTVFTVFMLAASGI CIILNVAEVVYLIIRACARRAQRRSNPPSRKGSGFGHRLSPEYKQNEINK LLSEQDGSLKDILRRSPGTGAGLAEKSDRCSAC
      • Amino acids

        1 to 283
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab158522 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      Western blot

    • Form

      Liquid
    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • Charcot Marie Tooth neuropathy X linked
      • CMTX
      • CMTX 1
      • CMTX1
      • Connexin-32
      • Connexin32
      • CX 32
      • Cx32
      • CXB1_HUMAN
      • GAP junction 28 kDa liver protein
      • Gap junction beta 1 protein
      • Gap junction beta-1 protein
      • Gap junction protein beta 1
      • Gap junction protein beta 1 32kD
      • GJB 1
      • GJB1
      see all
    • Function

      One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
    • Involvement in disease

      Defects in GJB1 are the cause of Charcot-Marie-Tooth disease X-linked type 1 (CMTX1) [MIM:302800]; also designated CMT-X. CMTX1 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies characterized by severely reduced motor nerve conduction velocities (NCVs) (less than 38m/s) and segmental demyelination and remyelination, and primary peripheral axonal neuropathies characterized by normal or mildly reduced NCVs and chronic axonal degeneration and regeneration on nerve biopsy. CMTX1 has both demyelinating and axonal features. Central nervous system involvement may occur.
      Defects in GJB1 may contribute to the phenotype of Dejerine-Sottas syndrome (DSS) [MIM:145900]; also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie-Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome.
    • Sequence similarities

      Belongs to the connexin family. Beta-type (group I) subfamily.
    • Cellular localization

      Cell membrane. Cell junction > gap junction.
    • Target information above from: UniProt accession P08034 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human Connexin 32 / GJB1 protein (ab158522)
      SDS-PAGE - Recombinant Human Connexin 32 / GJB1 protein (ab158522)
      ab158522 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (0)

    Publishing research using ab158522? Please let us know so that we can cite the reference in this datasheet.

    ab158522 has not yet been referenced specifically in any publications.

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