Recombinant Human COPS6 protein (ab132862)
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Overview
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Product name
Recombinant Human COPS6 protein
See all COPS6 proteins and peptides -
Protein length
Full length protein
Description
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Nature
Recombinant -
Source
Wheat germ -
Amino Acid Sequence
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Accession
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Species
Human -
Sequence
MAAAAAAAAATNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILN ISDHWIRMRSQEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIII DKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPL FLKLNPMTKHTDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGV DHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEV PFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCN TMNQFVNKFNVLYDRQGIGRRMRGLFF -
Molecular weight
63 kDa including tags -
Amino acids
1 to 327
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Specifications
Our Abpromise guarantee covers the use of ab132862 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
SDS-PAGE
ELISA
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Form
Liquid -
Additional notes
Protein concentration is above or equal to 0.05 µg/µl. -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- COP9 (constitutive photomorphogenic), subunit 6; COP9 complex S6
- COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
- COP9 signalosome complex subunit 6
see all -
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. -
Tissue specificity
Widely expressed. -
Sequence similarities
Belongs to the peptidase M67A family. CSN6 subfamily.
Contains 1 MPN (JAB/Mov34) domain. -
Cellular localization
Nucleus. Cytoplasm. The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human COPS6 protein (ab132862)12.5% SDS-PAGE analysis of ab132862 stained with Coomassie Blue.
Datasheets and documents
References
ab132862 has not yet been referenced specifically in any publications.
