The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
cleavage and polyadenylation specific factor 6, 68kDa
Cleavage and polyadenylation specificity factor 68 kDa subunit
Cleavage and polyadenylation specificity factor subunit 6
cleavage factor Im complex 68 kDa subunit
CPSF 68 kDa subunit
Pre mRNA cleavage factor Im 68 kDa subunit
pre-mRNA cleavage factor I, 68kD subunit
pre-mRNA cleavage factor Im (68kD)
Pre-mRNA cleavage factor Im 68 kDa subunit
Protein HPBRII 4/7
Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.
Belongs to the RRM CPSF6/7 family. Contains 1 RRM (RNA recognition motif) domain.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Nucleus. In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.