The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
crumbs homolog 3 (Drosophila)
Crumbs protein homolog 3
crumbs, Drosophila, homolog of, 3
protein crumbs homolog 3
Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions.
Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate.
The PDZ-binding motif is involved in the interactions with PARD6A and MPP5.
Apical cell membrane. Cell junction > tight junction. Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells.