Recombinant Human CRMP4 protein (ab132289)

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Description

  • Product name

    Recombinant Human CRMP4 protein

  • Expression system

    Wheat germ

  • Accession

    Q14195

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLI VPGGVKTIEANGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGG TTMIIDHVVPEPESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQ EVQNLIKDKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQVHAE NGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAITIASQTNCPL YVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAA FVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTA IPEGTNGVEERMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGR ISVGSDSDLVIWDPDAVKIVSAKNHQSAAEYNIFEGMELRGAPLVVICQG KIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMADLHAVPRGMYD GPVFDLTTTPKGGTPAGSARGSPTRPNPPVRNLHQSGFSLSGTQVDEGVR SASKRIVAPPGGRSNITSLS

    • Predicted molecular weight

      88 kDa including tags

    • Amino acids

      1 to 570

Specifications

Our Abpromise guarantee covers the use of ab132289 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    ELISA

    Western blot

  • Form

    Liquid

  • Additional notes

     

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • Collapsin response mediator protein 4
    • Collapsin response mediator protein 4 long
    • CRMP 4
    • CRMP-4
    • CRMP4
    • Dihydropyrimidinase like 3
    • Dihydropyrimidinase related protein 3
    • Dihydropyrimidinase-related protein 3
    • DPYL3_HUMAN
    • DPYSL3
    • DRP 3
    • DRP-3
    • DRP3
    • LCRMP
    • TUC4
    • ULIP
    • ULIP 1
    • ULIP-1
    • ULIP1
    • Unc 33 like phosphoprotein
    • UNc 33 like phosphoprotein 1
    • Unc-33-like phosphoprotein 1
    see all

  • Function

    Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.

  • Tissue specificity

    Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.

  • Sequence similarities

    Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

  • Post-translational
    modifications

    Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.

  • Cellular localization

    Cytoplasm. Cell projection > growth cone. Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human CRMP4 protein (ab132289)
    SDS-PAGE - Recombinant Human CRMP4 protein (ab132289)
    12.5% SDS-PAGE stained with Coomassie Blue showing ab132289.

References

ab132289 has not yet been referenced specifically in any publications.

Publishing research using ab132289? Please let us know so that we can cite the reference in this datasheet.

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