Recombinant Human CRTAM protein (ab163368)

Product name

Recombinant Human CRTAM protein
See all CRTAM proteins and peptides
Protein length

Full length protein

Our Abpromise guarantee covers the use of ab163368 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- CD355
- Class I MHC restricted T cell associated molecule
- Class-I MHC-restricted T-cell-associated molecule
- CRTAM
- CRTAM_HUMAN
- Cytotoxic and regulatory T cell molecule
- Cytotoxic and regulatory T-cell molecule
see all
Function

Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.
Tissue specificity

In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues.
Sequence similarities

Belongs to the nectin family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Cellular localization

Membrane.
Target information above from: UniProt accession O95727 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human CRTAM protein (ab163368)

ab163368 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ab163368 has not yet been referenced specifically in any publications.

Publishing research using ab163368? Please let us know so that we can cite the reference in this datasheet.

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