Recombinant human CSK protein (ab60764)
- Datasheet
- References
- Protocols
Overview
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Product nameRecombinant human CSK protein
See all CSK proteins and peptides -
Protein lengthFull length protein
Description
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NatureRecombinant
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SourceBaculovirus infected Sf9 cells
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Amino Acid Sequence
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SpeciesHuman
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Associated products
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Related Products
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Substrate reagent
Specifications
Our Abpromise guarantee covers the use of ab60764 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Functional Studies
SDS-PAGE
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FormLiquid
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Additional notes
ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.50
Constituents: 0.0038% EGTA, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol, 0.87% Sodium chlorideThis product is an active protein and may elicit a biological response in vivo, handle with caution.
General Info
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Alternative names
- C SRC
- C SRC kinase
- C src Tyrosine Kinase
see all -
FunctionSpecifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.
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Tissue specificityExpressed in lung and macrophages.
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Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain. -
Post-translational
modificationsAutophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro. -
Cellular localizationCytoplasm. Cell membrane. Mainly cytoplasmic, also present in lipid rafts.
- Information by UniProt
Images
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Functional Studies - Recombinant human CSK protein (ab60764)Sample Kinase Activity Plot. -
SDS-PAGE - Recombinant human CSK protein (ab60764)ab60764 on SDS-PAGE, MW ~52kDa.
Datasheets and documents
References
ab60764 has not yet been referenced specifically in any publications.
