Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMKYLLP EVTVLDYGKK CVVIDLDETL VHSSFKPISN ADFIVPVEID GTIHQVYVLK RPHVDEFLQR MGQLFECVLF TASLAKYADP VADLLDRWGV FRARLFRESC VFHRGNYVKD LSRLGRELSK VIIVDNSPAS YIFHPENAVP VQSWFDDMTD TELLDLIPFF EGLSREDDVY SMLHRLCNR
    • Molecular weight

      24 kDa including tags
    • Amino acids

      82 to 265
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab123182 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry

    MALDI-TOF
  • Purity

    > 90 % SDS-PAGE.
    ab123182 is purified using conventional chromatography.
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 40% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names

    • C3orf8
    • Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3
    • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
    • CTD small phosphatase-like protein
    • CTDSL_HUMAN
    • CTDSP-like
    • Ctdspl
    • hYA22
    • N-like protein
    • NIF-like protein
    • NLI-interacting factor 1
    • Nuclear LIM interactor-interacting factor 1
    • Protein YA22
    • RB protein serine phosphatase from chromosome 3
    • RBSP3
    • SCP3
    • Small C-terminal domain phosphatase 3
    • Small CTD phosphatase 3
    see all
  • Function

    Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
  • Tissue specificity

    Expression is restricted to non-neuronal tissues.
  • Sequence similarities

    Contains 1 FCP1 homology domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab123182 (3ug)

References

ab123182 has not yet been referenced specifically in any publications.

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