Description

  • Product name

    Recombinant human CTRP5 protein
  • Biological activity

    Activates AMPK signaling pathway in rat L6 myoblasts.
  • Purity

    > 90 % SDS-PAGE.
    ab109041 was 0.2µm filtered
  • Endotoxin level

    < 1.000 Eu/µg
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      26 kDa including tags
    • Amino acids

      16 to 243
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab109041 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    pH: 8.20
    Constituents: 0.869% Tris HCl, 0.87% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute in distilled water

General Info

  • Alternative names

    • C1q and tumor necrosis factor related protein 5
    • C1QTNF5
    • Complement C1q tumor necrosis factor related protein 5 precursor
    • LORD
  • Relevance

    Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. CTRP5 has been suggested to be involved in age-related macular degeneration.
  • Cellular localization

    Secreted

Images

  • ab109041 activates AMPK signaling pathway in rat L6 myoblasts.
    Differentiated rat L6 myoblasts were stimulated with control buffer or 0.5μg/ml ab109041 for 30min. The cell lysate was subjected to immunoblotting with antibodies against pAMPK and total AMPK.

References

ab109041 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab109041.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up